|Year : 2019 | Volume
| Issue : 3 | Page : 143-148
Effect of acupressure in Pericardium 6 acupoint on nausea and vomiting after general surgery
Jamshid Eslami1, Isan Darvishi2, Abed Ebrahimi2, Marzieh Akbarzadeh3
1 Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
3 Maternal – Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
|Date of Web Publication||1-Aug-2019|
Maternal – Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz
Source of Support: None, Conflict of Interest: None
Background: Nausea and vomiting are of the most common postoperative complications. Postoperative nausea and vomiting (PONV) can increase the patients' length of hospital stay, healthcare costs, and perioperative morbidity. Objective: The current study aimed to evaluate the effects of acupressure in preventing PONV in patients who have undergone general surgery with spinal anesthesia. Methods: This single-blind clinical trial was performed on 70 patients who had undergone general surgery and randomly assigned to an intervention and a control group. In the intervention group, the acupressure wristbands were fastened to one of the patients' wrist so that the pressing buttons were placed on the Pericardium 6 acupoint. In the control group, the wristbands without pressing buttons were loosely fastened on the desired point. The severity and episodes of nausea and vomiting were measured intraoperatively, 1, 3, and 7 h postoperatively. The data were analyzed via repeated measures analysis, t, and Chi-square tests. Results: Over time, the intervention significantly decreased the mean of nausea episodes (P < 0.001), nausea severity (P < 0.001), and vomiting episodes (P < 0.001) in the intervention group. In the comparison of the two groups, the repeated measures analysis showed that although after the intervention the values of all the three variables was lower in the intervention group than that of the control group, but these difference were only statistically significant in the episodes and the severity of nausea. Conclusion: The acupressure significantly reduced the severity and episode(s) of postoperative nausea, but it did not affect vomiting.
Keywords: Acupressure, Nausea, Pericardium 6 acupoint, Vomiting
|How to cite this article:|
Eslami J, Darvishi I, Ebrahimi A, Akbarzadeh M. Effect of acupressure in Pericardium 6 acupoint on nausea and vomiting after general surgery. Nurs Midwifery Stud 2019;8:143-8
|How to cite this URL:|
Eslami J, Darvishi I, Ebrahimi A, Akbarzadeh M. Effect of acupressure in Pericardium 6 acupoint on nausea and vomiting after general surgery. Nurs Midwifery Stud [serial online] 2019 [cited 2020 Jan 26];8:143-8. Available from: http://www.nmsjournal.com/text.asp?2019/8/3/143/263866
| Introduction|| |
Nausea and vomiting are of the most common postoperative complications and of important nursing diagnoses. The incidence of nausea and vomiting varies from 20% to 30% depending on the type of surgery and the factors related to the patient. Postoperative nausea and vomiting (PONV) in patients having undergone spinal anesthesia are multifactorial, and a number of factors such as physiological changes, intraoperative hypotension, visceral stimulation, and administration of opioids may affect it. PONV increases the length of stay, healthcare costs, and perioperative morbidity. A number of medicines are usually used to treat PONV. However, they bring some complications. For instance, somnolence, extrapyramidal signs and symptoms, headache, and diarrhea may occur after administration of metoclopramide. Ondansetron may also causes diarrhea, headache, and transient changes in the level of hepatic enzymes. Therefore, nurses and physicians are seeking some noninvasive, inexpensive, and easy approaches to reduce PONV. Nonpharmacologic strategies such as hypnosis, acupuncture, acupressure, relaxation techniques, behavioral therapy, and guided imagery are recommended to prevent PONV.
Acupressure is a noninvasive method induced by manual stimulation. Several studies evaluated the effects of acupressure on reducing postoperative pain, nausea, and vomiting.,, A study reported the remarkable effects of acupressure in the Pericardium 6 (PC6) acupoint on postdelivery pain. Another study also revealed the significant effects of acupressure in PC2 acupoint located in the index finger on reducing PONV in patients who had undergone laparotomy. Some studies were carried out to evaluate the effects of PC6 acupressure on PONV and reported controversial findings., A number of studies have reported the significant effects of acupressure on decreasing PONV in patients undergone gynecologic surgeries, laparoscopic cholecystectomy, and appendectomy. Conversely, a study reported that PC6 acupressure was not effective in declining PONV in patients who had undergone laparoscopic cholecystectomy. Another study on the effect of PC6 acupressure after abdominal surgeries reported that it has little effect and requires further studies. Most of the aforementioned studies have undertaken on patients who have received general anesthesia, and no study is available on the effect of PC6 acupressure on PONV in patients receiving spinal anesthesia.
The current study aimed to evaluate the effects of acupressure in PC6 acupoint on PONV in patients having undergone general surgery with spinal anesthesia.
| Methods|| |
Study design and participants
The current study was a single-blind clinical trial performed on 70 male and female patients who were referred to Shiraz University of Medical Sciences and Health Services training hospitals and had undergone general surgery with spinal anesthesia.
The sample size was estimated using the findings of a previous study in which the effect of PC6 acupressure on PONV was assessed, and the postintervention mean and standard deviation of vomiting episodes in the experimental and the control group were 0.22 ± 0.71 and 1.9 ± 2.17, respectively. Then, considering β = 0.1, α = 0.01, S1=0.71, S2=2.17, μ1=0.22, and μ2=1.9, 20 individuals were estimated to be needed in each group. However, considering a possible dropout of 20% in repeated measures and for increasing the study accuracy, we recruited 35 cases in each group [Figure 1].
After sample size calculation, permuted block randomization was used to assign patients into two groups in a 1:1 ratio. Then, 12 blocks of 6 were prepared, and the patients were consecutively assigned to the blocks until the sample size in each group was completed.
The inclusion criteria were being in the age range of 15–60 years old, having no problem in the PC6 acupoint, being candidate for a general surgery with spinal anesthesia, having no history of comorbidities leading to acute or chronic nausea and vomiting such as digestive and auditory disorders, having no history of nausea and/or vomiting during the past 24 h, having no addiction to opioids and alcohol, having no history of neurological disorders based on the patient's self-report, having a body temperature <38° centigrade, and having no history of using acupressure. A patient's decision to withdraw from the study, needing medication due to severe nausea and/or vomiting, and the emergence of unexpected intraoperative complications were considered as the exclusion criteria.
The acupressure or control wristbands were fastened on PC6 point on one of the patients' wrists. The PC6 acupoint is located on the palmar side of the wrist two inches above the transverse crease of the wrist, between the tendons of palmaris longus and flexor carpi radialis. An easy way to find the point is to place three fingers across your wrist starting at the wrist crease; then, look at the point where this line crosses between the two tendons [Figure 2]a.
|Figure 2: Location of Pericardium 6 acupoint (a) and wristbands on the Pericardium 6 acupoint (b) psi Band acupuncture bracelet for nausea and vomiting|
Click here to view
Intervention and measurements
The acupressure wristband used in the current study was PsiBand [Figure 2]b designed by a company at the United States and assembled in China. To use the wristband, the researcher was trained in a short course under the supervision of an expert in Traditional Chinese Medicine (TCM).
The wristbands were fastened to the patients' wrists immediately before the spinal anesthesia started. In the intervention group, the acupressure wristbands were placed on the PC6 acupoint in a way that the pressing button compresses the desired point. The amount of pressure was set by turning the knob on the wristband while considering the size of the patient's wrists for obesity and slimming. The wristbands were in place for 7 h. The pressure of the wristband was so much that it causes no harm to the point and no disturbance in the radial artery blood flow and the venous return of the hand. A nurse periodically inspected the point and examined the radial pulse and the color and temperature of the hand. Moreover, a trained research assistant loosened the wristbands for 10 min and tightened them again hourly. In the control group, the acupressure wristbands without the pressing button were loosely placed on the PC6 acupoint and were kept in place for 7 hour. The severity and episodes of nausea and the episodes of vomiting were measured four times including intraoperative time, 1, 3, and 7 hour postoperatively.
A two-part instrument was used to collect the study data. The first part included questions on the patients' demographic variables such as sex, age, education level, occupation, and marriage. The second part was a visual analog scale (VAS). The VAS was a 10 cm line graded from 0 to 10. Descriptors were placed at each end of the line (0 = no nausea, 10 = the most severe nausea). Patients were asked to mark an X on the place that corresponded with the severity of nausea they experienced. Then, scores 0, 1–3, 4–7, and 8–10 were classified as no nausea, mild, moderate, and severe nausea, respectively. The validity and reliability of the VAS were confirmed in several studies., The episodes of nausea and vomiting were measured by recording their numbers. Recordings were done at the four aforementioned times.
The research project was approved by the local Ethics Committee of Shiraz University of Medical Sciences (Grant no.IR.SUMS.6396.31), and written informed consent was obtained from all the participants. The protocol was designed in accordance with the ethical principles of the Helsinki Declaration (World Medical Association, 2002). The patients were given a verbal lecture and written information about the goals and approach of the project, and then, they accepted to participate in the study. They all were also assured about the confidentiality of their personal information, and then, all of them signed the study informed consent form. The research proposal was financially supported by endocrine and metabolism research center, Shiraz University of Medical Sciences and also was registered at the Iranian Registry of Clinical Trials with the registration number of IRCT2017061134475.
Data analysis was carried out using SPSS software version 16 (IBM Company Armonk, NY, USA). Independent samples t-test was used to compare the mean of quantitative variables between the two groups. Chi-square test was used to compare the nominal and categorical variables of the two groups. Repeated measures analysis was used to compare the mean nausea episodes, nausea severity, and vomiting episodes in the two groups through the four subsequent measurement time points. The Mauchly's test was used to examine the sphericity of the dependent variable. Wilks' Lambda test was used for interpreting the results and t-test for pairwise comparisons. The significance level in all testes was set at < 0.05.
| Results|| |
A total of 70 male and female patients were enrolled in the study; with the age ranged 15–60 years. The mean age in the intervention and control groups was 38.92 ± 12.11 and 35.91 ± 12.71, respectively. The two groups did not significantly differ from each other respecting demographic characteristics except for the education level (P = 0.027) [Table 1].
In repeated measures analysis, the values of Mauchly's test were not significant (P > 0.05), so the assumption of sphericity was not violated. Then, the Wilks' Lambda test was used to interpret the effect of the intervention. The results showed that over time, the intervention significantly decreased the mean of nausea episodes (P < 0.001), nausea severity (P < 0.001), and vomiting episodes in the intervention group [P < 0.001; [Table 2].
|Table 2: Comparison of the mean and standard deviation of nausea episodes, nausea severity, and vomiting episodes in different time points|
Click here to view
Furthermore, the repeated measures analysis showed that the interaction between the group and time on the variables of nausea episodes and nausea severity were statistically significant but that was not the case in term of vomiting episodes [Table 2].
In the comparison of the two groups, the repeated measures analysis showed that although after the intervention the values of all the three variables was lower in the intervention group than that of the control group, these difference were only statistically significant in the episodes and the severity of nausea. However, due to the significant interaction between time and group in some of the variables, t-test was used for between group comparisons of the three variables in all the four measurement time points. The results showed that the mean of all the thee variables studied (i.e. nausea episodes, nausea severity, and vomiting episodes) were significantly lower in the intervention group than in the control group except for the nausea episodes at the 1 h postoperatively (P = 0.304), the nausea severity (P = 0.560), and the vomiting episodes (P = 059) at baseline intraoperative measurements [Table 2].
| Discussion|| |
Most of the earlier studies on the effect of acupressure on PONV have been conducted in patients receiving general anesthesia.,,,, However, in this study, we examined the effect of PC6 acupressure on PONV in patients receiving spinal anesthesia.
The present study showed that the mean episodes of nausea were less in the group received the PC6 acupressure than in the control group 1, 3, and 7 h postoperatively. The intervention group has also experienced less severe nausea than that of the control group at 3 and 7 postoperative hour. In line with our results, several studies examined the effect of acupressure of PC6 point,,,,,,] or other acupoints,,,,, on postoperative nausea episodes and reported its beneficial effects. Conversely, some studies reported that PC6 acupressure has no or little effect in declining postoperative nausea in patients undergoing laparoscopic and abdominal surgeries. Less nausea experience is effective in reducing patient suffering as a result, less anti-inflammatory drugs will be used after surgery. However, the inconsistencies between the studies might be attributable to several methodological factors such as incorrect determining of the location of the PC6 point, insufficient duration, and the type and amount of pressure applied on the acupoint. Moreover, the study sample size and populations studied might have affected the results in various studies.
The present study also showed that PC6 acupressure could decrease the episodes of postoperative vomiting, especially from the 1st postoperative hour on. A number of recent studies also evaluated the effects of PC6 acupressure on nausea and vomiting after ambulatory surgeries and appendectomy and reported fewer episodes and less severity of nausea and vomiting in those who received acupressure than in the control groups. However, another study has reported that this method could not reduce nausea and vomiting after laparoscopic cholecystectomy. A study has also reported that PC6 acupressure had a better effect on postoperative nausea than on vomiting. In a recent study, the PC6 acupressure was neither clinically nor statistically effective in decreasing postoperative vomiting. The inconsistencies between the studies might again be attributed to the type of surgery, duration of intervention, and type and the gender of the patients studied.
Overall, given the current results and the findings of earlier studies, it appears that applying pressure on PC6 acupoint might decrease PONV. Due to the important role of acupressure in decreasing PONV, the allied health professionals and specially nurses can use this method as a noninvasive, inexpensive, and simple complementary method to decrease PONV.
Different theories exist as the mechanism of this intervention. The first is the energy balance theory. According to the TCM, there is a vital force in the human body that keeps the physical strength. This force is known as “Chi-square” or vital energy and flows through the inaccessible networks under the skin, called meridians. Perhaps, pressing the PC6 acupoint eliminates energy congestion in the chest and stomach, calms the mind, and helps reduce thirst, nausea, and travel sickness. Another theory is the neurohormonal response theory. Based on this theory, the electromagnetic signals cause the activation of endorphins and monoamines. An increase in the serotonin level may also reduce nausea and vomiting. The third theory is the psychological factors theory. In this theory, the presence of the person performing acupressure is considered as a stress reliever.,,, However, a combination of the above reasons might affect the beneficial effects of acupressure on PONV.
A limitation of the current study was the probably different human physiological reactions to anesthesia that we were unable to measure it. Moreover, in the opposite of many earlier studies, our patients were under spinal anesthesia and therefore were awake during the surgery. This might affect their psychological condition and their reaction to acupressure. The small sample size is also another factor which might limit the generalizability of our results. Moreover, the effect of acupressure might be affected by the patients' age. Therefore, further studies with larger sample sizes and in different age groups such as adolescents, middle aged, and older adults are suggested. As for the different incidence of PONV in different surgeries, it is suggested that the effect of acupressure in different surgeries should be evaluated.
| Conclusion|| |
The mean episodes and severity of nausea in the intervention group was significantly lower than the control group. Vomiting episode in the intervention group was lower than the control group, but the difference was not significant. In the current study, acupressure of PC6 acupoint could reduce PONV in patients who have undergone spinal anesthesia. Therefore, it can be utilized by anesthetists and nurses in pre- and post-operative care. Nurses should be trained on using this nonpharmacologic method to treat PONV.
We would like to thank Shiraz University of Medical Sciences, Shiraz, Iran and also Center for Development of Clinical Research of Nemazee Hospital and Dr. Nasrin Shokrpour for editorial assistance. We also thank all the patients who participated in this study.
Financial support and sponsorship
This article is a part of Ms. Isan Darvishi's thesis (project number: 6396), which was approved and sponsored by Shiraz University of Medical Sciences. The study was financially supported by endocrine and metabolism research center, Shiraz University of Medical Sciences.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Chung JW, Lui JC. Postoperative pain management: Study of patients' level of pain and satisfaction with health care providers' responsiveness to their reports of pain. Nurs Health Sci 2003;5:13-21.
Moysés AM, Durant LC, Almeida AM, Gozzo TO. Integrative review of factors related to the nursing diagnosis nausea during antineoplastic chemotherapy. Rev Lat Am Enfermagem 2016;24:e2812.
Tramèr MR. Treatment of postoperative nausea and vomiting. BMJ 2003;327:762-3.
Hamilton BE, Martin JA, Ventura SJ. Births: Preliminary data for 2007. Natl Vital Stat Rep 2009;57:1-23.
Smith HS, Smith EJ, Smith BR. Postoperative nausea and vomiting. Ann Palliat Med 2012;1:94-102.
Samad K, Afshan G, Kamal R. Effect of acupressure on postoperative nausea and vomiting in laparoscopic cholecystectomy. J Pak Med Assoc 2003;53:68-72.
Andión O, Cañellas M, Baños JE. Physical well-being in postoperative period: A survey in patients, nurses and physicians. J Clin Nurs 2014;23:1421-9.
Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg 2006;102:1884-98.
Dupuis LL, Robinson PD, Boodhan S, Holdsworth M, Portwine C, Gibson P, et al.
Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients. Pediatr Blood Cancer 2014;61:1506-12.
Adib-Hajbaghery M, Etri M. Effect of acupressure of Ex-Le7 point on pain, nausea and vomiting after appendectomy: A randomized trial. J Res Med Sci 2013;18:482-6.
Lee MK, Chang SB, Kang DH. Effects of SP6 acupressure on labor pain and length of delivery time in women during labor. J Altern Complement Med 2004;10:959-65.
Kim KS, Koo MS, Jeon JW, Park HS, Seung IS. Capsicum plaster at the Korean hand acupuncture point reduces postoperative nausea and vomiting after abdominal hysterectomy. Anesth Analg 2002;95:1103-7.
Agarwal A, Bose N, Gaur A, Singh U, Gupta MK, Singh D. Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy. Can J Anaesth 2002;49:554-60.
Alkaissi A, Evertsson K, Johnsson VA, Ofenbartl L, Kalman S. P6 acupressure may relieve nausea and vomiting after gynecological surgery: An effectiveness study in 410 women. Can J Anaesth 2002;49:1034-9.
Sadri B, Maddah M, Rahimzadeh Bajgiran P. Evaluation of acupressure effects on the control of postoperative nausea and vomiting after gynecologic diagnostic laparascopy under general anesthesia in Hazrat-Rasool medical complex. Razi J Med Sci 2005;12:113-8.
Adib-Hajbaghery M, Etri M, Hosseinian M. The effect of acupressure on the pericardium 6 point on pain, nausea and vomiting after appendectomy. Complement Med J Fac Nurs Midwifery 2012;2:171-82.
Sakurai M, Suleman MI, Morioka N, Doufas AG, Akca O. Minute sphere acupressure does not reduce postoperative pain or morphine consumption. Anesthesiology 2002;96:A870.
Eghbali M, Yekaninejad MS, Varaei S, Jalalinia SF, Samimi MA, Sa'atchi K. The effect of auricular acupressure on nausea and vomiting caused by chemotherapy among breast cancer patients. Complement Ther Clin Pract 2016;24:189-94.
Naseri K, Shami S, Ahsan B, ZojajiKohan M. Effect of acupressure on post operative nausea and vomiting. Bimon J Hormozgan Univ Med Sci 2007;10:357-62.
Direkvand-Moghadam A, Khosravi A. Effect of acupressure on post-operative nausea and vomiting in cesarean section: A randomised controlled trial. J Clin Diagn Res 2013;7:2247-9.
Nikbakht Nasrabadi A, Alizadeh Z, Imanipour M, Hosseini SM, Sadrosadat SH, Heshmat R. Effect of acupressure on nausea in patients undergoing strabismus surgery. Hayat 2012;17:26-35.
Soltanzadeh M, Behaeen K, Pourmehdi Z, Safarimohsenabadi A. Effects of acupressure on nausea and vomiting after gynecological laparoscopy surgery for infertility investigations. Life Sci J 2012;9:871-5.
Taspinar A, Sirin A. Effect of acupressure on chemotherapy-induced nausea and vomiting in gynecologic cancer patients in Turkey. Eur J Oncol Nurs 2010;14:49-54.
Hirš I, Lukić A, Fumić NN, Kekić M, Kotaran J. Acupressure and metoclopramide comparison in postoperative nausea and vomiting prevention on laparatomy patients. Acupunct Relat Ther 2013;1:42-5.
Noroozinia H, Mahoori A, Hasani E, Gerami-Fahim M, Sepehrvand N. The effect of acupressure on nausea and vomiting after cesarean section under spinal anesthesia. Acta Med Iran 2013;51:163-7.
Kim NC, Yoo JB, Cho MS, Shin EJ, Hahm TS. Effects of nei-guan acupressure on nausea, vomiting and level of satisfaction for gynecological surgery patients who are using a patient-controlled analgesia. J Korean Acad Nurs 2010;40:423-32.
Hofmann D, Murray C, Beck J, Homann R. Acupressure in management of postoperative nausea and vomiting in high-risk ambulatory surgical patients. J Perianesth Nurs 2017;32:271-8.
Adib-Hajbaghery M, Etri M, Hosseainian M, Mousavi MS. Pressure to the p6 acupoint and post-appendectomy pain, nausea, and vomiting: A randomized clinical trial. J Caring Sci 2013;2:115-22.
Ünülü M, Kaya N. The effect of neiguan point (P6) acupressure with wristband on postoperative nausea, vomiting, and comfort level: A randomized controlled study. J Perianesth Nurs 2018;33:915-27.
Yilmaz Sahin S, Iyigun E, Can MF. Effect of acupressure application to the P6 acupoint before laparoscopic cholecystectomy on postoperative nausea-vomiting: A randomized controlled clinical study. Int J Nurs Stud 2018;87:40-8.
Barnes J. Pregnancy (6) Complementary therapies in pregnancy. Pharm J 2003;270:402-4.
Cheng KJ. Neuroanatomical characteristics of acupuncture points: Relationship between their anatomical locations and traditional clinical indications. Acupunct Med 2011;29:289-94.
Cheng KJ. Neurobiological mechanisms of acupuncture for some common illnesses: A clinician's perspective. J Acupunct Meridian Stud 2014;7:105-14.
Kwon CY, Lee B. Acupuncture or acupressure on Yintang (EX-HN 3) for anxiety: A Preliminary review. Med Acupunct 2018;30:73-9.
Moradi Z, Akbarzadeh M, Moradi P, Toosi M, Hadianfard MJ. The effect of acupressure at GB-21 and SP-6 acupoints on anxiety level and maternal-fetal attachment in primiparous women: A randomized controlled clinical trial. Nurs Midwifery Stud 2014;3:e19948.
Akbarzadeh M, Moradi Z, Hadianfard MJ, Zare N, Jowkar A. Comparison of the effect of mono-stage and bi-stage acupressure at SP6 point on the severity of labor pain and the delivery outcome. Int J Community Based Nurs Midwifery 2013;1:165-72.
Akbarzadeh M, Masoudi Z, Zare N, Vaziri F. Comparison of the effects of doula supportive care and acupressure at the BL32 point on the mother's anxiety level and delivery outcome. Iran J Nurs Midwifery Res 2015;20:239-46.
[Figure 1], [Figure 2]
[Table 1], [Table 2]